Baseline characteristics and outcomes of patients with COVID-19 admitted to intensive care units in Vancouver, Canada: a case series.

Baseline characteristics and outcomes of patients with COVID-19 admitted to intensive care units in Vancouver, Canada: a case series. CMAJ. 2020 May 27;: Authors: Mitra AR, Fergusson NA, Lloyd-Smith E, Wormsbecker A, Foster D, Karpov A, Crowe S, Haljan G, Chittock DR, Kanji HD, Sekhon MS, Griesdale DEG Abstract BACKGROUND: Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with high intensive care unit (ICU) mortality. We aimed to describe the clinical characteristics and outcomes of critically ill patients with coronavirus disease 2019 (COVID-19) in a Canadian setting. METHODS: We conducted a retrospective case series of critically ill patients with laboratory-confirmed SARS-CoV-2 infection consecutively admitted to 1 of 6 ICUs in Metro Vancouver, British Columbia, Canada, between Feb. 21 and Apr. 14, 2020. Demographic, management and outcome data were collected by review of patient charts and electronic medical records. RESULTS: Between Feb. 21 and Apr. 14, 2020, 117 patients were admitted to the ICU with a confirmed diagnosis of COVID-19. The median age was 69 (interquartile range [IQR] 60-75) years, and 38 (32.5%) were female. At least 1 comorbidity was present in 86 (73.5%) patients. Invasive mechanical ventilation was required in 74 (63.2%) patients. The duration of mechanical ventilation was 13.5 (IQR 8-22) days overall and 11 (IQR 6-16) days for patients successfully discharged from the ICU. Tocilizumab was...
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research

Related Links:

Next week, we’ll be wrapping up Coronapod in its current form. Please fill out our short survey to let us know your thoughts on the show.In this episode:02:15 Simulating pandemicsResearchers have run numerous military-style simulations to predict the consequences of fictitious viral outbreaks. We discuss how these simulations work, what recommendations come out of them and if any of these warnings have been heeded.24:08 One good thingOur hosts pick out things that have made them smile in the last week, including audience feedback, the official end of the Ebola outbreak in the northeastern Democratic Republic of the C...
Source: Nature Podcast - Category: Science Authors: Source Type: podcasts
Authors: Santos CDSE, Filho LMDCL, Santos CAT, Neill JS, Vale HF, Kurnutala LN Abstract The 2020 pandemic caused by the novel coronavirus, COVID-19, had its headquarters in China. It causes Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and presents a broad spectrum of clinical manifestations, ranging from entirely asymptomatic through severe acute respiratory failure and death. Presuming a significant quantity of ventilator-dependent patients, several institutions strategically delayed elective surgeries. Particularly procedures performed involving the nasal mucosa, such as a transsphenoidal approach...
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently become a pandemic. As the sudden emergence and rapid spread of SARS-CoV-2 is endangering global health and the economy, the development of strategies to contain the virus's spread are urgently needed. At present, various diagnostic kits to test for SARS-CoV-2 are available for use to initiate appropriate treatment faster and to limit further spread of the virus. Several drugs have demonstrated in vitro activity against SARS-CoV-2 or potential clinical benefits. In addition, institutions and companies worl...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
i The “Severe Acute Respiratory Syndrome Coronavirus Type 2” (SARS-CoV-2) has been identified as the infectious agent responsible for the generally mild but sometimes life-threatening communicable disease known as “Coronavirus Disease 2019” (COVID-19) [...]
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Editorial Source Type: research
At the time of reception of this article (April 2, 2020), efforts to develop a specific vaccine against SARS-Cov-2, the causative agent of the coronavirus disease 2019 (COVID-19), had just begun trial phase 1, but full validation of this and other current developments is likely to take many more months to reach completion. The ongoing pandemic constitutes a major health burden of world proportions that is also having a devastating impact on whole economies worldwide, the knock-on effects of which could be catastrophic especially in poorer countries. Alternative measures to ameliorate the impact and hamper or minimally slow...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In December 2019, a series of pneumonia cases of unknown cause was reported in Wuhan, Hubei, China. Shortly a novel coronavirus was isolated from respiratory tract samples named as SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). The new virus rapidly spread globally resulting in a pandemic. SARS-CoV-2 belongs to betacoronavirus as the severe acute respiratory syndrome (SARS) and the middle east respiratory syndrome (MERS) viruses responsible for serious outbreaks in China in 2002 –2003 and in the Middle East in 2012, respectively [1].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Review Source Type: research
Authors: Siah KTH, Rahman MM, Ong AML, Soh AYS, Lee YY, Xiao Y, Sachdeva S, Jung KW, Wang YP, Oshima T, Patcharatrakul T, Tseng PH, Goyal O, Pang J, Lai CKC, Park JH, Mahadeva S, Cho YK, Wu JCY, Ghoshal UC, Miwa H Abstract During the Coronavirus Disease 2019 (COVID-19) pandemic, practices of gastrointestinal procedures within the digestive tract require special precautions due to the risk of contraction of severe acute respiratoy syndrome coronavirus-2 (SARS-CoV-2) infection. Many procedures in the gastrointestinal motility laboratory may be considered moderate to high-risk for viral transmission. Healthcare staff ...
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
The global pandemic caused by the newly described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused worldwide suffering and death of unimaginable magnitude from coronavirus disease 2019 (COVID-19). The virus is transmitted through aerosol droplets, and causes severe acute respiratory syndrome. SARS-CoV-2 uses the receptor-binding domain of its spike protein S1 to attach to the host angiotensin-converting enzyme 2 receptor in lung and airway cells. Binding requires the help of another host protein, transmembrane protease serine S1 member 2.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Review article Source Type: research
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, most attention has focused on containing transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and addressing the surge of critically ill patients in acute care settings. Indeed, as of 29 April 2020, over 3 million confirmed cases have been accounted for globally [1]. In the coming weeks and months, emphasis will gradually involve also post-acute care of COVID-19 survivors. It is anticipated that COVID-19 may have a major impact on physical, cognitive, mental and social health status, also in patients with mild disease presen...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
The novel severe acute respiratory syndrome coronavirus 2019 (COVID-19) was declared a global pandemic by the World Health Organization on March 11, 2020.1 Reports have noted right ventricular longitudinal strain to be a strong predictor of mortality in patients with COVID-19.2 While left ventricular global longitudinal strain (GLS) has been well validated as a prognostic cardiovascular marker,3 the utility of left ventricular GLS in risk stratification of COVID-19 remains unknown. We assessed the association of left ventricle GLS in patients with COVID-19.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
More News: Actemra | Canada Health | Coronavirus | COVID-19 | Electronic Medical Records (EMR) | General Medicine | Hospitals | Hydroxychloroquine | Intensive Care | Laboratory Medicine | Pandemics | Respiratory Medicine | SARS | Study | UK Health