Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

This study establishes gasdermin-mediated pyroptosis as a cytotoxic lymphocyte–killing mechanism, which may enhance antitumor immunity.

Source: ScienceNOW - May 27, 2020 Category: Science Authors: Zhou, Z., He, H., Wang, K., Shi, X., Wang, Y., Su, Y., Wang, Y., Li, D., Liu, W., Zhang, Y., Shen, L., Han, W., Shen, L., Ding, J., Shao, F. Tags: Cell Biology, Immunology, Online Only r-articles Source Type: news