Incidence and risk factors for hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of Turkish Hematology Research and Education Group (ThREG)

Hepatic sinusoidal obstruction syndrome (HSOS) is a potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively evaluated the incidence, risk factors, treatment and survival for HSOS after allo-HSCT in Turkey. We also reported our experience of defibrotide (DF) for HSOS prophylaxis in high-risk (HR) patients. Across Turkey, 1153 patients from 10 centers were enrolled in the study. We evaluated the medical records of patients who were treated with allo-SCT between January 2012 and December 2015.

Source: Transfusion and Apheresis Science - May 24, 2020 Category: Hematology Authors: Nur Soyer, Mehmet Gunduz, Emre Tekgunduz, Burak Deveci, Hakan Ozdogu, Handan Haydaroglu Sahin, Esra Ermis Turak, Mufide Okay, Irfan Kuku, Ipek Yonal Hindilerden, Pervin Topcuoglu, Fevzi Altuntas, Ihsan Karadogan, Mustafa Pehlivan, Ali Unal, Hakan Goker, M Source Type: research