The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload

In conclusion, a purely biomechanical insult of RV pressure overload resulted in biomechanical and transcriptional changes in both the RV and LV. Give n that the RV relies on the LV for contractile energy assistance, considering the LV could provide prognostic and therapeutic targets for treating RV failure in PH.

Source: Physiological Reports - May 4, 2020 Category: Physiology Authors: Vitaly O. Kheyfets, Melanie J. Dufva, Mario Boehm, Xuefeit Tian, Xulei Qin, Jennifer E. Tabakh, Uyen Truong, Dunbar Ivy, Edda Spiekerkoetter Tags: ORIGINAL RESEARCH Source Type: research