Systemic treatment of brain metastases in non-small cell lung cancer

Brain metastases (BrMs) are associated with significant morbidity and are found in up to 50% of patients with advanced non-small cell lung cancer (NSCLC).Most of the literature focuses on symptomatic BrMs, with a lack of baseline brain imaging in asymptomatic patients. Unfortunately, much of the data on local treatments with or without systemic treatment is retrospective. Clinical trials of systemic treatments largely exclude patients with BrMs.Chemotherapy is an active treatment for BrM with response rates in the brain similar to other sites of disease.

Source: European Journal of Cancer - May 3, 2020 Category: Cancer & Oncology Authors: Simon Page, Charlotte Milner-Watts, Marco Perna, Urska Janzic, Natalia Vidal, Naila Kaudeer, Merina Ahmed, Fiona McDonald, Imogen Locke, Anna Minchom, Jaishree Bhosle, Liam Welsh, Mary O'Brien Tags: Review Source Type: research