Nuclear-mitochondrial communication involving miR-181c plays an important role in cardiac dysfunction during obesity

In cardiomyocytes, there is microRNA (miR) in the mitochondria that originates from the nuclear genome and matures in the cytoplasm before translocating into the mitochondria. Overexpression of one such miR, miR-181c, can lead to heart failure by stimulating reactive oxygen species (ROS) production and increasing mitochondrial calcium level ([Ca2+]m). Mitochondrial calcium uptake 1 protein (MICU1), a regulatory protein in the mitochondrial calcium uniporter complex, plays an important role in regulating [Ca2+]m.

Source: Journal of Molecular and Cellular Cardiology - May 18, 2020 Category: Cytology Authors: Barbara Roman, Pawandeep Kaur, Deepthi Ashok, Mark Kohr, Roopa Biswas, Brian O'Rourke, Charles Steenbergen, Samarjit Das Source Type: research