Evaluation of Glutathione Bioactivity on Toxoplasma Gondii in BALB/c Mice Post Impact of Selenium and Calcium Supplementation.

Evaluation of Glutathione Bioactivity on Toxoplasma Gondii in BALB/c Mice Post Impact of Selenium and Calcium Supplementation. Infect Disord Drug Targets. 2020 May 16;: Authors: Namazi MJ, Nikpour S, Rahimi-Moghaddam P, Hosseini SA, Siyadatpanah A, Mostafavi NSS, Golmohammadi R, Tabatabaie F Abstract Studies have shown that selenium is an essential component of glutathione as an important antioxidant to reduce oxidative stress and inhibit intracellular parasites' growth. In contrast, calcium in cytosol of such parasites plays a key role in entry of the parasite into the host cell and its primary motility. The present study was designed to evaluate and compare glutathione peroxidase bioactivity effects post administration of selenium and calcium in BALB/c mice infected by Toxoplasma gondii (Table 3) Sixty BALB/c mice susceptible to T. gondii were randomly divided into twelve groups of case and control groups. There were six control groups including two positive controls infected only with the paraites either 104 or 5×104 , non-infcetd and untreated groups, Treated controls were received only calcium, selenium, or both respectively. Case groups were infected with 104 or 5×104 parasites. While each set of three case groups separately received minerals alone or together. Mice were orally fed with 200 μg selenium, 50 μg calcium or their combination for 7 days. Mice were infected by parasite's tachyzoites. Sera of mice were kept and th...
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research