Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice

Conclusions Local sympathetic nerves control the progression of immune responses in dorsal root ganglia and pain-like behaviors in mice after paclitaxel, raising the possibility that clinical strategies already in use for local sympathetic blockade may also offer an effective treatment for patients experiencing chemotherapy-induced neuropathic pain.Editor ’s PerspectiveWhat We Already Know about This TopicChemotherapy-induced neuropathic pain is a common and difficult-to-treat problemInflammation may support chemotherapy-induced pain by interacting with sensory neuronsWhat This Article Tells Us That Is NewLocal surgical sympathectomy relieved nociceptive and mechanical sensitization in a mouse model of paclitaxel-induced painTransforming growth factor- β was enhanced in mice after sympathectomy and was capable of reducing paclitaxel-induced mechanical sensitization
Source: Anesthesiology - Category: Anesthesiology Source Type: research