Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.

Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.
Curr Protein Pept Sci. 2020 May 06;:
Authors: Al-Hamashi AA, Diaz K, Huang R
Abstract
Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent post-transitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and how PRMT-mediated non-histone arginine methylation modulates various diseases. Additionally, we highlight the most recent clinical studies for several PRMT inhibitors.
PMID: 32379587 [PubMed - as supplied by publisher]

Source: Current Protein and Peptide Science - May 5, 2020 Category: Biochemistry Authors: Al-Hamashi AA, Diaz K, Huang R Tags: Curr Protein Pept Sci Source Type: research