Plasma element levels and risk of chronic kidney disease in elderly populations ( ≥ 90 Years old).

Plasma element levels and risk of chronic kidney disease in elderly populations (≥ 90 Years old). Chemosphere. 2020 Apr 17;254:126809 Authors: Shen Y, Yin Z, Lv Y, Luo J, Shi W, Fang J, Shi X Abstract Associations between plasma elements and chronic kidney disease (CKD) among the elderly are poorly understood. In this cross-sectional study, we explored the associations between exposure to four plasma elements and CKD in elderly people aged ≥90 years in longevity areas in China. We measured plasma selenium, manganese, iron, and zinc levels and used logistic regression models to investigate associations between CKD and these four plasma elements after adjusting for confounding factors among 461 participants aged ≥90 years in the fifth wave of the Chinese Longitudinal Healthy Longevity Study (CLHLS) conducted in 2009. The median plasma selenium, manganese, iron, and zinc levels were 120.51 μg/L, 26.64 μg/L, 2880.52 μg/L, and 1882.42 μg/L in the CKD group and 108.76 μg/L, 31.55 μg/L, 4512.00 μg/L, and 2294.24 μg/L in the non-CKD group, respectively. Single- and multiple-element multivariable models showed that plasma manganese, iron, and zinc were negatively associated with CKD. In the multiple-element multivariable models, the adjusted odds ratios for CKD were 0.48 (95% confidence interval [CI]: 0.27-0.86) for the second highest quartile of manganese, 0.37 (95% CI: 0.21-0.68) and 0.36 (95% CI: 0.19-0.65) for the t...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research