Trigonella foenum-graecum L. Sprouted Seed Extract: Its Chemical HPLC Analysis, Abortive Effect, and Neurodevelopmental Toxicity on Mice.

Trigonella foenum-graecum L. Sprouted Seed Extract: Its Chemical HPLC Analysis, Abortive Effect, and Neurodevelopmental Toxicity on Mice. Evid Based Complement Alternat Med. 2020;2020:1615794 Authors: Oufquir S, Ait Laaradia M, El Gabbas Z, Bezza K, Laadraoui J, Aboufatima R, Sokar Z, Chait A Abstract The Trigonella foenum-graecum L. seeds, in a dormant or sprouted state, have been largely investigated for their therapeutic activities such as being antidiabetic, antioxidant, cholesterol-lowering, and as a digestive enhancer too. Nevertheless, there are no studies evaluating the potential developmental toxicity of germinated grains despite the availability of numerous research studies demonstrating the teratogenicity effect of unsprouted seeds. Therefore, this research work was conducted to assess the impact of fenugreek sprouts on maternal and neurobehavioral developmental toxicities on mice. The lyophilized aqueous extract of germinated seeds was administered via oral gavage on a daily basis to five groups of mated female mice throughout pregnancy at doses of 200, 500, 800, and 1000 mg/kg/day and the control group was administered distilled water. Maternal reproductive toxicity was evaluated, and the surviving pups were assessed for their physical development, malformation, and neurobehavioral toxicity by using a battery of tests from birth to the 25th postnatal day. Additionally, the aqueous extract of germinated and ungerminated...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research