Sacubitril/Valsartan Therapy Ameliorates Ventricular Tachyarrhythmia Inducibility in a Rabbit Myocardial Infarction Model

Coronary artery disease is the most common cause of heart failure (HF) in developed countries. Ventricular tachycardia (VT)/ventricular fibrillation (VF) are the most common causes of sudden cardiac death (SCD) in patients with postmyocardial infarction (MI) HF. Pharmacologic therapies have been shown to reduce mortality levels in these patients, and most of those medications involve the sympathetic nervous system and the renin-angiotensin-aldosterone pathway, such as beta-blockers, angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers (ARBs), and aldosterone antagonists.

Source: Journal of Cardiac Failure - March 20, 2020 Category: Cardiology Authors: Po-Cheng Chang, Hung-Ta Wo, Hui-Ling Lee, Shien-Fong Lin, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou Source Type: research