Effects of condensed organic matter on PCBs bioavailability in juvenile swine, an animal model for young children.

This study involved fourteen juvenile male swine as a digestive physiology model of young children. Animals were randomly distributed into 4 contaminated groups (3 replicates) and a control one (2 replicates). During 10d, the piglets were fed AS or a corn oil spiked with 19200ng of Aroclor 1254 per g of dry matter (6000ngg(-1) of NDL-PCBs) to achieve an exposure dose of 1200ngNDL-PCBskg(-1) of body weight per day. After 10d of oral exposure, NDL-PCBs in adipose tissue, liver and muscles were analyzed by GC-MS, after extraction and purification. Two distinct groups of treatments were found: on the one hand oil, SS and FA, on the other hand C and AC. This study highlights that condensed OM (AC) strongly reduces bioavailability whereas the less condensed one (FA) does not seem to have a significant effect. This result has to be considered as a first major step for further relative bioavailability studies involving mixture of different humic substances. PMID: 24289980 [PubMed - as supplied by publisher]
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research