Perioperative management of oral cleft repair: a retrospective chart review.
Perioperative management of oral cleft repair: a retrospective chart review.
Paediatr Anaesth. 2020 Apr 10;:
Authors: Shrimpton AJ, Gill H
Abstract
Pre-clinical evidence has shown all common anesthetic drugs are toxic to the developing brain1 . Despite numerous cohort studies and one randomised control trial (RCT)2 , it remains unclear whether anesthetic-induced neurotoxicity exists and if intraoperative physiological disturbance plays a role. Well-designed RCTs with long-term follow-up are required to examine this. Infants requiring repair of oral cleft may provide an optimal clinical model; they often undergo multiple surgeries and have routine, nationally agreed, long-term speech and language assessments which extend into early adulthood.
PMID: 32275794 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Shrimpton AJ, Gill H Tags: Paediatr Anaesth Source Type: research
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