In Reply, Endothelin-1 and the Anrep Effect

We appreciate Dr. Houston's consideration of whether circulating Endothelin-1 ’s (ET1) hypothesized role in the Anrep effect could explain our findings of a lower risk for incident heart failure in healthy subjects.1 The Anrep effect describes the observation that sustained elevation in left ventricular end-diastolic volume leads to increases in myocardial contractility and ventricular unloading over many minutes, which is distinct from the more rapid Frank-Starling mechanism. On a tissue level, the Anrep effect may stem from slow force response (SFR) whereby myocardial stretch causes increased calcium transient amplitude and enhanced contractility.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research