Trans-Right–Ventricle and Transpulmonary MicroRNA Gradients in Human Pulmonary Arterial Hypertension*

Objectives: We investigated whether concentrations of circulating microRNAs differ across the hypertensive right ventricle and pulmonary circulation, and correlate with hemodynamic/echocardiographic variables in patients with pulmonary arterial hypertension versus nonpulmonary arterial hypertension controls. Design: Prospective blood collection during cardiac catheterization from the superior vena cava, pulmonary artery, and ascending aorta in 12 children with pulmonary arterial hypertension and nine matched nonpulmonary arterial hypertension controls, followed by an unbiased quantitative polymerase chain reaction array screen for 754 microRNAs in plasma. Setting: Children’s hospital at a medical school. Patients: Twelve pulmonary arterial hypertension patients included as follows: idiopathic pulmonary arterial hypertension (5), pulmonary arterial hypertension (2), pulmonary arterial hypertension-repaired congenital heart disease (4), portopulmonary pulmonary hypertension (1). Nine nonpulmonary arterial hypertension controls included as follows: mild/moderate left ventricular outflow tract obstruction (7), mediastinal teratoma (1), portal vein stenosis (1). Interventions: Standard pulmonary arterial hypertension treatment. Measurements and Main Results: Analysis of differential concentrations (false discovery rate
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Feature Cardiac Intensive Care Source Type: research

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Publication date: Available online 30 May 2020Source: Journal of American Association for Pediatric Ophthalmology and StrabismusAuthor(s): Gamze Dereli Can, Muhammet Furkan Korkmaz, Mehmet Erol Can
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - Category: Opthalmology Source Type: research
Authors: Infusino F, Cimino S, Lombardi M, Mancone M, Cavarretta E, Frati G, Pugliese F, Fedele F, Biondi-Zoccai G Abstract SARS-CoV-2 is spreading rapidly all over the world. The case fatality rate seems higher in cardiovascular disease and hypertension. Other comorbidities do not seem to confer the same risk, therefore the understanding of the relationship between infection and cardiovascular system could be a crucial point for the fight against the virus. A great interest is currently directed towards the angiotensin 2 converting enzyme (ACE 2) which is the SARS-CoV-2 receptor and creates important connections b...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Authors: Rong LQ, Neuburger PJ, Kim J, Devereux RB Abstract Global longitudinal strain (GLS) has emerged as a valuable diagnostic and prognostic tool for evaluating left ventricular (LV) function. GLS has been shown to be a more sensitive marker of LV dysfunction than LV ejection fraction alone and have prognostic impact in non-surgical cardiac populations. GLS, is validated, reproducible, and easily obtained from 2-dimensional speckle- tracking echocardiography. While there is strong evidence for using GLS in clinical decision- making in non-surgical populations, there is less summarized evidence on using GLS in t...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
HIGH blood pressure symptoms can be difficult to spot, but may include severe headaches, chest pain, and finding blood in your urine. You could lower your chances of deadly hypertension symptoms and signs by smelling lavender oil, it's been claimed. Should you check your blood pressure?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Oszukowska M, Kozłowska M, Kaszuba A Abstract Introduction: Psoriasis is considered as a risk factor for atherosclerosis and contributes to myocardial infarction, ischemic heart disease and brain stroke. Aim: To estimate the atherogenic potential of psoriasis by analysing antioxidative and prooxidative factors (paraoxonase-1, α-tocopherol, uric acid, homocysteine), compare levels of these parameters between groups of psoriatic patients and healthy individuals as well as to analyse the impact of psoriasis severity and duration on the factors under the study and to define correlation between the m...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
CONCLUSIONS: Better staff training focused on care bundles preventing infections, better medical training focused on less efforts for CVC insertion, and the use of Ultrasounds during the CVC insertion may be the main factors that can lead to lower CLABSI rates in obese patients. Further research relating CLABSI rates in ICU patients and obesity is needed. PMID: 32468303 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
aacute;lez J. Alfredo Martínez Health related quality of life (HRQoL) is a subjective appreciation of how personal characteristics and health influence well-being. This cross-sectional analysis aimed to quantitatively measure the influence of dietary, lifestyle, and demographic factors on HRQoL. A sub-sample of the Seguimiento Universidad de Navarra (SUN) Project, a Mediterranean cohort, was analyzed (n = 15,674). Through self-administered questionnaires the relationship between HRQoL and dietary patterns (Mediterranean-diet (MedDiet) and provegetarian food pattern (FP) assessment), lifestyles (sleeping hours,...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Heart disease is the leading cause of mortality in adult women. Beyond the traditional risk factors of obesity, diabetes, and hypercholesterolemia, women with the pregnancy complications of preeclampsia, gestational diabetes, prematurity, and low birth weight for gestational age (fetal growth restriction) are at higher risk for later development of cardiovascular disease. Education of women and providers about the association of pregnancy complications and cardiovascular disease should begin in the postpartum period. Postpartum cardiovascular risk screening and lifestyle modifications should be considered standard of care ...
Source: Obstetrics and Gynecology Clinics - Category: OBGYN Authors: Source Type: research
HEART attack symptoms include difficulty breathing, severe chest pain, and feeling sick. But, you could also be at risk of a deadly myocardial infarction and heart disease if your toes turn a strange colour. This is the skin condition you should avoid.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 29 May 2020Source: Pregnancy HypertensionAuthor(s): Mamoru Morikawa, Michinori Mayama, Yoshihiro Saito, Kinuko Nakagawa, Takeshi Umazume, Kentaro Chiba, Satoshi Kawaguchi, Kazutoshi Cho, Hidemichi Watari
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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