Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension.

Conclusions: These data demonstrate that Bmpr2 mutation affects RV stress responses in a transgenic rodent model. Impaired RV hypertrophy and triglyceride and ceramide deposition are present as a function of RV mutant Bmpr2 in mice; fatty acid oxidation impairment in human HPAH RVs may underlie this finding. Further study of how BMPR2 mediates RV lipotoxicity is warranted. PMID: 24274756 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24274756?dopt=Abstract

Source: American Journal of Respiratory and Critical Care Medicine - November 25, 2013 Category: Respiratory Medicine Authors: Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J Tags: Am J Respir Crit Care Med Source Type: research