GSE130402 MiRNA-mediated induction of mesenchymal-to-epithelial transition (MET) between cancer cell types is significantly modulated by inter-cellular molecular variability

Contributors : Mengnan Zhang ; Yuehua Wang ; Lilya V Matyunina ; Amber Akbar ; John F McDonaldSeries Type : Expression profiling by arrayOrganism :Recent years have witnessed a dramatic increase in our appreciation of the contribution of microRNAs (miRNAs) to cancer onset and progression. As a consequence, there has been growing interest in the development of miRNAs not only as diagnostic biomarkers of cancer but also as a promising new class of therapeutic agents. Over the last several years, our laboratory has focused on analysis of the molecular processes underlying the ability of individual miRNAs to induce mesenchymal-to-epithelial transition (MET) particularly in ovarian cancer. Ectopic over expression of specific miRNAs down regulated during epithelial-to mesenchymal transition (EMT) have previously been reported to induce MET in a variety of cancer cells, thereby reducing metastatic potential and resistance to standard-of-care chemotherapies. Interestingly, the ability of individual miRNAs to induce MET when over expressed in cancer cells is often cancer/cell-type specific. In an effort to better understand the molecular processes underlying this specificity, we examined the molecular and phenotypic responses of three mesenchymal-like cancer cell lines (two ovarian and one prostate) to ectopic over expression of three sequentially divergent miRNAs previously implicated in the EMT/MET process. The ability of these sequentially divergent miRNAs to induce MET in these...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research