Colonization profile and duration by multi-resistant organisms in a prospective cohort of newborns after hospital discharge.

Colonization profile and duration by multi-resistant organisms in a prospective cohort of newborns after hospital discharge. Rev Inst Med Trop Sao Paulo. 2020;62:e22 Authors: Sakai AM, Iensue TNAN, Pereira KO, Silva RLD, Pegoraro LGO, Salvador MSA, Rodrigues R, Capobiango JD, Souza NAA, Pelisson M, Vespero EC, Yamauchi LM, Perugini MRE, Yamada-Ogatta SF, Rossetto EG, Kerbauy G Abstract The aim of this study was to determine the spontaneous decolonization period and characteristics in a prospective cohort of newborns colonized by multidrug-resistant organisms, after their discharge from the neonatal intensive care unit. Multidrug resistance is defined as bacterial non-susceptibility to ≥ 1 agent of ≥ 3 antimicrobial categories. In total, 618 newborns were included in the study, of which 173 (28.0%) presented a positive culture for multidrug-resistant microorganisms, and of these, 52 (30.1%) were followed up in this study. The most frequent intrinsic factors were be born by cesarean section (86.5%), prematurity (84.6%), and very low birth weight (76.9%). The extrinsic factors were having remained hospitalized for an average of 27 days, during which 67.3% were submitted to invasive procedures and 88.5% received antimicrobials. The intrinsic and extrinsic factors of newborns were not associated to a decolonization period longer or shorter than 3 months, which was the average period of decolonization found in the present study. From t...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research