[Treatment de-intensification strategies for HPV-driven oropharyngeal cancer: A short review].

[Treatment de-intensification strategies for HPV-driven oropharyngeal cancer: A short review]. Cancer Radiother. 2020 Mar 27;: Authors: Lahmamssi C, Guy JB, Benchekroun N, Bouchbika Z, Taoufik N, Jouhadi H, Sahraoui S, Benider A, Ben Mrad M, Jmour O, Bousarsar A, Lan ML, Lei Q, Benna M, Moslemi D, Vallard A, Magné N Abstract The incidence of oropharyngeal cancer induced by human papillomavirus (HPV) infection is steadily increasing in developed countries. These tumors are more chemoradiosensitive and have a better prognosis than HPV-negative one. In addition, they occur in younger and better-off patients with longer life expectancy. Current radiotherapy and chemotherapy protocols are currently being questioned as they may expose HPV-positive patients to excessive treatment and unnecessary toxic effects. Less intensive treatment regimens could possibly achieve similar efficacy with lower toxicity and improved quality of life. The aim of this work was to summarize the knowledge on these tumors and their implications for radiation oncologists. In this update, we will discuss ongoing de-escalation trials and highlight the issues raised by these studies. We will also comment on the results of recently published de-intensification studies. Three main strategies are analyzed in the present article: the de-escalation of the drug associated with radiotherapy, the de-escalation of the radiotherapy dose (in concomitant chemoradiotherapy, after...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research