Improvement of Hemodynamics in a Left Ventricular Assist Device Using Heuristic Aerodynamic Strategies to Redesign the Bladed Flow Domain

In this study, a typical axial flow LVAD was redesigned using aerodynamics-based strategies to improve its hemodynamics and hence clinical outcomes for recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1044) Source Type: research

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Acquired von Willebrand syndrome is implicated in the pathology of gastrointestinal bleeding (GIB) after implantation of continuous-flow left ventricular assist systems (CF-LVAS). Adults with blood type (BT) O have lower circulating levels of von Willebrand factor. In this analysis, we sought to explore the association between BT O and GIB following CF-LVAS implantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (38) Source Type: research
Increased shear stress conferred upon the circulation by continuous flow pumps is associated with hemocompatibility related adverse events, principally bleeding within the gastrointestinal system, and linked to degradation of high molecular weight multimers (HMWM) of von Willebrand factor (vWF). We evaluated the structure and functional characteristics of vWF HMWM in patients with the fully magnetically levitated centrifugal-flow HeartMate 3 (HM3) and the continuous axial-flow HeartMate II (HMII) pump.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Mechanical circulatory support devices are needed to enable recovery or provide a bridge to decision for patients with heart failure. The effectiveness of extending treatment duration in this therapy was previously reported to increase adverse events, such as acquired von Willebrand disease and gastrointestinal bleeding. Blood-related damage caused by medical devices is one of the most critical parameters needed to determine the performance of medical devices. For the treatment of these complications, we considered that it is very important to analyze the relationship between the cleavage of von Willebrand factor (VWF) due...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1083 Source Type: research
In this study, we aimed to prospectively compare the perioperative time-course of angiopoietin-1 (Ang1), angiopoietin-2 (Ang2) and von Willebrand Factor (vWF) between HeartMate II (HMII) and HeartMate 3 (HM3) patients in correlation with postoperative complications.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1073 Source Type: research
It has been proposed that the high prevalence of bleeding events in continuous-flow left ventricular assist device (CF-LVAD) patients may be lowered by increasing von Willebrand factor-release via augmented peripheral pulsatility (PI). However, the hemostatic effects of increased PI may be offset by concomitant increases in local wall shear stress (WSS) - which is known to stimulate the endothelial release of anti-thrombotic factors (NO, prostacyclin, thrombomodulin).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1070 Source Type: research
Gastrointestinal (GI) bleeding, primarily manifesting as angiodsyplasia (AGD) is one of the most common and challenging complications post CF LVAD. The possible mechanisms underlying LVAD induced AGD formation are the subject of intense research efforts and have focused on an association with low or absent pulsatility and acquired type 2A von Willebrand factor deficiency (vWD). We have previously reported a high prevalence of nasal mucosal vascular malformations, a possible surrogate marker for AGD, in patients with heart failure (HF) prior to LVAD implant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
In this study, we attempted to correlate the speed of STMCSD to the HMWM loss and bleeding.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
This study was performed to determine the onset of AVWS after implantation and the recovery of von Willebrand factor (VWF) parameters after explantation of ECMO in a large cohort of patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Veno-venous membrane oxygenation (vvECMO) is increasingly applied as a bridge to lung transplant and a lifesaving procedure during treatment for severe Acute Respiratory Distress Syndrome (ARDS). ECMO-mortality (42% - 58%), however, remains unacceptably high.1,2 The main complication resulting from ECMO-therapy is hemorrhage, with a reported incidence between 30%2 and 60%.3 Bleeding from catheter insertion sites, mucous membranes and the lung is common. Almost 10% of patients even suffer from spontaneous intracranial bleeding, raising mortality up to 80%.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
This study was performed to determine the onset of AVWS after implantation and the recovery of von Willebrand factor (VWF) parameters after explantation of ECMO in a large cohort of patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
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