Determining the Properties of Omecamtiv Mecarbil on Human Explanted Cardiac Trabeculae and Its Interaction with Current Inotropes via the Beta 1-Adrenoceptor

Omecamtiv mecarbil (OM) is a first in class selective myosin activator, developed to increase contractile force without altering intracellular calcium concentrations in patients with advanced heart failure (AHF). We sought to investigate the effect of OM on contractility, arrhythmia genesis and interaction with Beta 1-adrenoceptor (B1AR) inotropes directly on explanted human failing heart.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (895) Source Type: research