Trends in Blood Urea Nitrogen to Creatinine Ratio between Listing and Heart Transplant are Associated with Poor Post-Transplant Outcomes

Non-dialysis dependent patients with renal impairment undergoing heart transplantation (HT) alone are at higher risk of mortality and poor renal outcomes compared to those undergoing heart-kidney transplantation (HKT). It remains unclear what parameters might identify patients who may benefit from HKT compared to HT. We investigated whether interval changes in blood urea nitrogen to creatinine ratio (BCR) between listing and transplant in those with stage 3 chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) 30 - 59 ml/min/1.73 m2) are associated with higher risk of post-HT death or worsening renal function (WRF).

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: R. Gupta, L.R. Punnoose, J. Marvin-Peek, K.H. Schlendorf, A. Shah, D.M. Brinkley, J.N. Menachem, M. Wigger, S.B. Sacks, H. Ooi, K.R. Balsara, J.R. Hoffman, J. Lindenfeld, S. Zalawadiya Tags: (620) Source Type: research