Postoperative Heparinization Monitoring by Anti-Xa is More Accurate Than by APTT after Pulmonary Endarterectomy - Role of Increased Systemic and Endothelial Production of Factor VIII

Pulmonary endarterectomy (PEA) is curative for suitable chronic thromboembolic pulmonary hypertension (CTEPH) patients. Careful anticoagulation prevents postoperative bleeding and thromboembolic recurrence. Heparinization is often guided by aPTT but it can be influenced by Factor VIII - a coagulation factor elevated in CTEPH. Anti-Xa-guided anticoagulation is less affected by other factors. We investigated the correlation between aPTT and Anti-Xa after PEA and the impact of coagulation factors.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (56) Source Type: research