Antibiotic prophylaxis for transrectal ultrasound-guided prostate needle biopsy: Compared efficacy of ciprofloxacin vs. the ciprofloxacin/fosfomycin tromethamine combination.

CONCLUSIONS: The adoption of CIP/FOS antibiotic prophylaxis significantly lowered the rate of post-PNB urosepsis. Conveniently, this regimen is oral, single-dose, and low-cost. PMID: 32209218 [PubMed - as supplied by publisher]
Source: Canadian Urological Association Journal - Category: Urology & Nephrology Authors: Tags: Can Urol Assoc J Source Type: research

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Abstract Clostridioides difficile infection (CDI) is one of the most common causes of nosocomial diarrhea in developed countries and the main cause in healthcare settings. This case-control study was designed to evaluate the composition of the gut microbiota dominant bacterial groups in patients with CDI compared to the healthy control subjects. A total of 100 adult subjects involving 50 inpatients with CDI and 50 healthy persons were enrolled in the study. C. difficile isolates were characterized according to the anaerobic culture and presence of toxin genes with multiplex PCR. An ecological analysis was performe...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research
Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil. Allergol Immunopathol (Madr). 2020 Feb 12;: Authors: Melli LCFL, Carmo-Rodrigues MSD, Araújo-Filho HB, Mello CS, Tahan S, Pignatari ACC, Solé D, Morais MB Abstract BACKGROUND: It is possible that imbalances in the composition of the gut microbiota or the relationship of the microbiota with the host may be implicated in the origin of allergy. Therefore, we studied the intestinal microbiota of children with atopic dermatitis (AD). METHODS: Cross-sectional study w...
Source: Allergologia et Immunopathologia - Category: Allergy & Immunology Authors: Tags: Allergol Immunopathol (Madr) Source Type: research
The Wnt/β-catenin signaling pathway is crucial to regulate cell proliferation and polarity, cell determination, and tissue homeostasis. The activation of Wnt/β-catenin signaling is based on the interaction between Wnt glycoproteins and seven transmembrane receptors—Frizzled (Fzd). This binding promotes recruitment of the scaffolding protein Disheveled (Dvl), which results in the phosphorylation of the co-receptor LRP5/6. The resultant molecular complex Wnt–Fzd–LRP5/6-Dvl forms a structural region for Axin interaction that disrupts Axin-mediated phosphorylation/degradation of the transcriptional ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study also found that Proteus DNA, a genus with many uropathogenic species (Drzewiecka, 2016), was more prevalent in women with OAB compared to asymptomatic controls (Curtiss et al., 2017). IC A recent study by Abernethy et al. suggested that the microbiome may play a role in IC (Abernethy et al., 2017). In this study, 16S rRNA analysis determined the microbiome of catheterized urine from women (n = 40) with IC was not dominated by a single genus and was less likely to contain Lactobacillus compared to asymptomatic women. Abernethy et al. also showed that L. acidophilus was associated with less severe scores on the ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Blessing O. Anonye1, Jack Hassall2, Jamie Patient3, Usanee Detamornrat3, Afnan M. Aladdad3, Stephanie Schüller4,5, Felicity R. A. J. Rose3 and Meera Unnikrishnan1* 1Microbiology and Infection Unit, Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom 2Warwick Integrative Synthetic Biology Centre, School of Life Sciences, University of Warwick, Coventry, United Kingdom 3Division of Regenerative Medicine and Cellular Therapies, School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom 4Norwich Medical School, F...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion There is growing interest in bolstering resistance to infections or diseases by altering the microbiota (Jia et al., 2008; Holmes, 2016; Waterman et al., 2016; Delzenne and Bindels, 2018). Here, we have presented a computational framework, i.e., iENA, to identify the key OTU features to distinguish normal and disease states, by extracting higher-order statistics and dynamic information from 16S rRNA (ribosomal RNA) gene sequencing data in a one-sample manner. As a proof-of-concept study, we carried out iENA on the temporal development data of twelve subjects (healthy adults) undergoing a challenge with intestin...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Guangwen Luo1†, Bailiang Li1†, Cailu Yang2†, Yutang Wang1, Xin Bian1, Wan Li1, Fei Liu1 and Guicheng Huo1* 1Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, China 2Department of Ultrasound, Maternal and Child Health Hospital of Dapeng New District, Shenzhen, China Modulating gut microbiota to promote host health is well recognized. Therefore, people consume dietary products containing traditional probiotics in wishing to improve their health, and they need more research-based advices on how to select products with sui...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion Human microbiome is normal flora for humans, which has been proved to be of symbiotic relationship with humans and harmless to humans. If the microbes that breed in the human body become “unhealthy,” it will definitely affect the host's physical condition. People are continuing to explore the pathologic relationship between microorganisms and the human body through high-throughput sequencing technologies and analysis systems. However, it is a pity that their pathogenesis cannot be fully understood as yet. Considering that relying only on conventional experimental methods is time-consuming an...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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