Study of Immunotherapy Combined With Chemotherapy in Locally Advanced and Metastatic Pancreatic Cancer

Condition:   Locally Advanced and Metastatic Pancreatic Cancer Interventions:   Drug: PD-L1/CTLA4 BsAb;   Combination Product: GP;   Combination Product: FOLFIRINOX Sponsor:   Changhai Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Longaker Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the resident pancreas parenchymal cell repair program. Many solid tumor types including pancreatic cancer have severe tumor fibrosis called desmoplasia. Desmoplastic stroma is coopted by the tumor as a support structure and CAFs aid in tumor growth, invasion, and metastases. This stroma is caused by cancer associated fibroblasts (CAFs), which lay down extensive connective tissue in and around the tumor cells. CAFs represent a heterogeneous populat...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Condition:   Pancreatic Cancer Interventions:   Biological: N-803;   Drug: Aldoxorubicin HCl;   Biological: PD-L1 t-haNK;   Drug: Nab-paclitaxel;   Drug: Gemcitabine;   Drug: Cyclophosphamide;   Drug: 5-Fluorouracil;   Drug: Leucovorin;   Procedure: SBRT;   Drug: Irinotecan liposome Sponsor:   ImmunityBio, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The main recurrence pattern for lung cancer patients after radical surgery is distant metastasis. The probability of pancreatic metastasis in patients diagnosed with lung squamous cell carcinoma is 0.02%, with a poor prognosis. Chemotherapy is the preferred treatment for recurrence. Single lesions or oligometastasis can be surgically resected, and local lesions with compression symptoms can be treated with radiotherapy. The FDA and NMPA have approved first ‐line indications for immunotherapy for lung squamous cell carcinoma. Here, we report the case of a 57‐year‐old male patient with lung squamous cell carcinoma who ...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
Conclusions: Tripartite treatment could be a novel therapeutic option for PC patients.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Condition:   Locally Advanced and Metastatic Pancreatic Cancer Interventions:   Drug: PD-L1/CTLA4 BsAb;   Combination Product: GP;   Combination Product: FOLFIRINOX Sponsor:   Changhai Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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