Ovarian Brenner tumour: A morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium
Conclusions: Our findings suggest a tubal origin of BTs through transitional metaplasia and Walthard cell nests, based on their anatomic proximity, similar IHC profile and the presence of cilia. In addition, we hypothesise a role of androgenic stimulation in the pathogenesis of BT, based on the IHC staining pattern of calretinin, inhibin and steroidogenic factor 1 expressed in the luteinised stromal cells surrounding the epithelial nests of the tumours, and AKR1C3 and androgen receptor expressed in both the epithelial and stromal components.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Elisabetta Kuhn, Ayse Ayhan, Ie-Ming Shih, Jeffrey D. Seidman, Robert J. Kurman Tags: Gynecologic oncology Source Type: research
More News: Borderline Tumor | Brenner Tumor | Cancer | Cancer & Oncology | Epithelial Cancer | Fallopian Tube Cancer | Ovarian Cancer | Ovaries | Study | Transitional Cell Carcinoma