Research Articles Noninvasive localization of cardiac arrhythmias using electromechanical wave imaging

This study evaluates the accuracy of EWI for localization of various arrhythmias in all four chambers of the heart before catheter ablation. Fifty-five patients with an accessory pathway (AP) with Wolff-Parkinson-White (WPW) syndrome, premature ventricular complexes (PVCs), atrial tachycardia (AT), or atrial flutter (AFL) underwent transthoracic EWI and 12-lead ECG. Three-dimensional (3D) rendered EWI isochrones and 12-lead ECG predictions by six electrophysiologists were applied to a standardized segmented cardiac model and subsequently compared to the region of successful ablation on 3D electroanatomical maps generated by invasive catheter mapping. There was significant interobserver variability among 12-lead ECG reads by expert electrophysiologists. EWI correctly predicted 96% of arrhythmia locations as compared with 71% for 12-lead ECG analyses [unadjusted for arrhythmia type: odds ratio (OR), 11.8; 95% confidence interval (CI), 2.2 to 63.2; P = 0.004; adjusted for arrhythmia type: OR, 12.1; 95% CI, 2.3 to 63.2; P = 0.003]. This double-blinded clinical study demonstrates that EWI can localize atrial and ventricular arrhythmias including WPW, PVC, AT, and AFL. EWI when used with ECG may allow for improved treatment for patients with arrhythmias.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research

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ConclusionUnderstanding these common links and central topologies under the perspective of systems biology and network theory and greater insights are provided to uncover the complex neurodegeneration processes. PMID: 32468556 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
This article is about "kinesia paradoxa," a phenomenon presented in Parkinson's disease patients who generally suffer from bradykinesia and freezing of gait (FOG) but under certain circumstances exhibit a sudden, brief period of mobility. The objective of this paper was to identify the mechanisms causing this phenomenon, record possible brain circuits involved, and try to locate interconnections between these circuits. Moreover, we are proposing various modeling schemes in order to form the appropriate conditions for experimental design. PMID: 32468533 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Abstract BACKGROUND: In contrast to adults, in whom cardiac rhythm disorders are mainly conditioned by coronary artery disease, in children, arrhythmias are most often associated with inherited heart disorders. Catheter ablation (CA) has an important role in the management of cardiac arrhythmias, in adults and children. The aim of the study was to assess and compare the efficacy and safety of CA in children and adults with preexcitation syndrome. METHODS: The study population comprised 43 adults and 43 children diagnosed with a Wolff-Parkinson-White syndrome (WPW). The mean age of the study population was 41 ...
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
on RH Abstract Cardiac arrhythmias, notably Wolff-Parkinson-White syndrome, are known to represent a major issue in patients with Ebstein's malformation of the tricuspid valve. Abnormal conducting circuits, however, can also be produced by pathways extending either from the atrioventricular node or the ventricular components of the atrioventricular conduction axis, direct to the crest of the muscular ventricular septum. We hoped to provide further information on the potential presence of such pathways by investigations of six autopsied examples of Ebstein's malformation. All were studied by histological sectioning...
Source: Journal of Anatomy - Category: Anatomy Authors: Tags: J Anat Source Type: research
We present a case of a young asymptomatic patient who developed acute atrial fibrillation with antegrade conduction over the atrioventricular bypass tract and very high ventricular rate after accidental low voltage electric injury, which was reverted successfully by DC shock. PMID: 31011403 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
AbstractPurpose of ReviewThe purpose of this paper is to review the presentation, mechanism and acute management of pediatric tachyarrhythmias and to discuss current updates in the literature.Recent FindingsIn 2015, the AHA updated the PALS guidelines to include lidocaine as a first line agent alongside amiodarone in the management of ventricular tachycardia. A recent study re-addressed the safety of the use of adenosine on heart transplant patients with supraventricular tachycardia (SVT). Also, there have been recent studies which explored alternative prevention modalities for postoperative junctional ectopic tachycardia ...
Source: Current Pediatrics Reports - Category: Pediatrics Source Type: research
Wolff-Parkinson-White (WPW) syndrome is a rare pre-excitation syndrome which develops when atrioventricular conduction occurs through a pathologic accessory pathway known as the bundle of Kent instead of atrioventricular node, hence resulting in tachycardia. Patients with WPW syndrome may experience various symptoms arising from mild-to-moderate chest disease, palpitations, hypotension, and severe cardiopulmonary dysfunction. These patients are most often symptomatic because of cardiac arrhythmias.
Source: Journal of Clinical Anesthesia - Category: Anesthesiology Authors: Tags: Case Report Source Type: research
Please wait while the activity loads. If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled. If loading fails, click here to try again Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test. Start Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 7. You scored %%SCORE%% out of %%TOTAL%%. Your performance has been rate...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
A recently developed, ECG-based, three dimensional (3D) electrocardiomapping modality named Electrocardiographic Imaging (ECGI) has refined non-invasive diagnosis of heart rhythm disorders [1][2][3]. Our clinical experience in using this non-invasive mapping technique to identify the sources of electrical disorders and guide catheter ablation of atrial arrhythmias (premature atrial beat, atrial tachycardia, atrial fibrillation), ventricular arrhythmias (premature ventricular beats) and ventricular pre-excitation (Wolff-Parkinson-White syndrome) is described below.
Source: Journal of Electrocardiology - Category: Cardiology Authors: Source Type: research
During epileptic seizures, cardiac arrhythmias are not uncommon findings. Most of them are benign, although sometimes they can be a life-threatening situation. The combination of a Wolff-Parkinson-White syndrome with atrial fibrillation is a potentially lethal situation but can be definitively treated.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Clinical letter Source Type: research
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