Efficacy of body weight vs body surface area-based prednisolone regimen in nephrotic syndrome

ConclusionsIn treating children with uncomplicated NS, both BSA and BW regimens were equally effective in achieving initial remission and maintaining disease remission. Due to fewer adverse events and lesser cumulative steroid exposure with BW based regimen, it may be considered as better option over BSA regimen.Clinical trial registry nameClinical Trial Registry of India (CTRI/2015/03/005655)
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research

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Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionTolvaptan was very efficient in this case of hyponatremia associated with steroid-resistant NS. Tolvaptan should be considered in the management of therapy-resistant hyponatremia in patients with NS.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 21 May 2020Source: IDCasesAuthor(s): Mwelwa Chizinga, Manzar Hussain, Katie Taylor, Saminder Kalra, Asmita Gupte, Muna Canales
Source: IDCases - Category: Infectious Diseases Source Type: research
CONCLUSIONS: In patients of African ancestry, imported Plasmodium infection may be a new causal factor for secondary FSGS, particularly for collapsing glomerulopathy variants in an APOL1 high-risk variant background. PMID: 32444394 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
No abstract available
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Editorial Source Type: research
Background: Tacrolimus dosing is routinely tailored based on its trough level (C0) drawn by therapeutic drug monitoring in pediatric patients with primary nephrotic syndrome. However, this concentration is often inaccurate owing to inappropriate practice, such as deviation of sampling time (DST). The quantitative relationship between DST and C0 remains unclear. Methods: Tacrolimus concentration at nominal sampling times (12 hours after last dose) and 32 deviation scenarios (12 ± 4 hours every 15 minutes) was predicted using a previously validated population pharmacokinetic model based on 162 scenarios of 100 pr...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Conclusions. These findings suggest that genetic testing for inherited thrombophilia in NS could play an important role in detecting high-risk patients that warrant prophylactic anticoagulation. PMID: 32438633 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
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