The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Protects Vascular Endothelial Function in Hypercholesterolemic Rats by Inhibiting Myeloperoxidase.

Conclusion: MPO might provoke vascular endothelial dysfunction in hypercholesterolemic rats by reducing the NO biological activity and impairing the NO/cGMP/cGK signaling pathway. PIO might inhibit vascular MPO activity and increase NO bioavailability with the net result of reversing endothelial dysfunction. PMID: 32190383 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/32190383?dopt=Abstract

Source: Cardiology Research and Practice - March 21, 2020 Category: Cardiology Authors: Zhang D, Wang Y, Yi M, Zhang S, Wu Y Tags: Cardiol Res Pract Source Type: research