Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping

Genetically caused nonalcoholic fatty liver disease (NAFLD) was found to cause diabetes mellitus and central obesity but protects against overall obesity; while diabetes and obesity also cause NAFLD. The study further suggested that each of the three closely related diseases, NAFLD, T2D and obesity should be further stratified to different subtypes. This is important for accurate diagnosis, prevention and treatment for these diseases.

Source: Journal of Hepatology - March 8, 2020 Category: Gastroenterology Authors: Zhipeng Liu, Yang Zhang, Sarah Graham, Xiaokun Wang, Defeng Cai, Menghao Huang, Roger Pique-Regi, Xiaocheng Charlie Dong, Y. Eugene Chen, Cristen Willer, Wanqing Liu Source Type: research