(-)-Epigallocatechin Gallate Promotes MicroRNA 145 Expression against Myocardial Hypoxic Injury through Dab2/Wnt3a/ β-catenin.

This study demonstrated that EGCG increased miR-145, Wnt3a, and β-catenin expression but attenuated Dab2 expression. Moreover, EGCG ameliorated myocardial ischemia in vivo. The novel suppressive effect was mediated through the miR-145 and Dab2/Wnt3a/β-catenin pathways.
PMID: 32138537 [PubMed - as supplied by publisher]

Source: The American Journal of Chinese Medicine - March 4, 2020 Category: Complementary Medicine Authors: Lin CM, Fang WJ, Wang BW, Pan CM, Chua SK, Hou SW, Shyu KG Tags: Am J Chin Med Source Type: research