Genomic and serologic characterization of enterovirus A71 brainstem encephalitis

Conclusion
mNGS with VirScan significantly increased the CNS detection of EVs relative to qRT-PCR, and the latter generated an antigenic profile of the acute EV-A71 immune response. Genomic analysis confirmed the close relation of the outbreak EV-A71 and neuroinvasive German EV-A71. A S241P substitution in VP1 was found exclusively in the CSF.

Source: Neurology Neuroimmunology and Neuroinflammation - March 4, 2020 Category: Neurology Authors: Leon, K. E., Schubert, R. D., Casas-Alba, D., Hawes, I. A., Ramachandran, P. S., Ramesh, A., Pak, J. E., Wu, W., Cheung, C. K., Crawford, E. D., Khan, L. M., Launes, C., Sample, H. A., Zorn, K. C., Cabrerizo, M., Valero-Rello, A., Langelier, C., Munoz-Alm Tags: All Infections, Encephalitis, Meningitis, Viral infections, All Pediatric Article Source Type: research