Pretreatment of nafithromycin attenuates inflammatory response in murine lipopolysaccharide induced acute lung injury.
Pretreatment of nafithromycin attenuates inflammatory response in murine lipopolysaccharide induced acute lung injury. Cytokine. 2020 Feb 29;129:155049 Authors: Trivedi J, Shaikh J, Chavan N, Thorve D, Chaudhary B, Karade A, Gupta S, Patel A, Bhagwat S Abstract Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI wherein the bacterial cell components play a crucial role. Macrolide/ketolide antibiotics are reported to possess immunomodulatory activity; as a result improved survival has been noted in pneumonia patients. Hence immunomodulatory activity of nafithromycin, a novel lactone ketolide antibacterial agent was assessed in the murine LPS induced ALI model. Vehicle, nafithromycin (100 mg/kg), azithromycin (600 mg/kg) and dexamethasone (20 mg/kg) were administered orally, 1 h prior to LPS challenge and bronchoalveolar lavage (BAL) fluid was collected thereafter at 18, 24 and 48 h to determine the total cell count, total protein, myeloperoxidase (MPO), tumor necrosis factor (TNF)-α and interleukin (IL)-6. Results from the current study showed that pretreatment with nafithromycin significantly reduced the total cell count, total protein, MPO, TNF-α and IL-6 ...
Publication date: Available online 4 July 2020Source: European UrologyAuthor(s): Amit Bansal, Anant Kumar
Publication date: Available online 4 July 2020Source: European UrologyAuthor(s): Lan Zhu, Gang Chen
Publication date: Available online 5 July 2020Source: Medical Mycology Case ReportsAuthor(s): Norma B. Fernandez, Diego H. Caceres, Karlyn Beer, Celica Irrazabal, Ghilka Delgado, Luciana Farias, Tom M. Chiller, Paul E. Verweij, Daniel Stecher
Authors: Schmid M PMID: 32616145 [PubMed - in process]
Conclusions: A diagnosis of HP should be considered in pediatric lung biopsies with granulomatous interstitial and peribronchial inflammation, if infectious etiologies are excluded. Integration of clinical, radiological, and laboratory findings can facilitate a timely diagnosis. PMID: 32619123 [PubMed - as supplied by publisher]
Dear Editor,The new emerging SARSCoV2 infection ‑causing pandemic COVID‑19 is a global public health problem at present. This disease was first reported in pneumonia patients in Chinabefore its occurrence in more than 150 countries worldwide.
Conclusions:iNOS is the cause of damage to host cells with a consequent pulmonary thromboembolic lung phenomenon in a contest of interstitial pneumonia. This study proposes the use of sildenafil to counter the inflammatory cascade and thromboembolic episodes.Keywords:COVID ‑19, nitric oxide, sildenafil citrate
AbstractAfter the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the last two decades, the world is facing its new challenge in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic with unprecedented global response. With the expanding domain of presentations in COVID-19 patients, the full range of manifestations is yet to unfold. The classical clinical symptoms for SARS-CoV-2 affected patients are dry cough, high fever, dyspnoea, lethal pneumonia whereas many patients have also been found to be associated with a few addi...
Publication date: Available online 3 July 2020Source: Respiratory InvestigationAuthor(s): Takahiro Takazono, Yoshifumi Imamura, Kaoru Kawakami, Naoya Yamasaki, Hiroyoshi Shimizu, Katsuhiro Usuki, Maiko Kiyohara, Tatsuro Hirayama, Masato Tashiro, Naoki Hosogaya, Tomomi Saijo, Kazuko Yamamoto, Taiga Miyazaki, Katsunori Yanagihara, Koichi Izumikawa, Hiroshi Mukae
Conclusion: CBCT-guided RFA of lung tumors is a relatively safe procedure with acceptable morbidity. PMID: 32619365 [PubMed - as supplied by publisher]