Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017

In this study, we performed phylogenetic, recombinant, and nucleotide variation analyses of 114 complete genome sequences of dengue virus serotypes 1–4 (DENV1-4) collected from 2013 to 2017 in 18 of 21 cities of Guangdong. Phylogenetic analyses revealed that DENV sequences d id not form a single cluster, indicating that dengue fever was not endemic in Guangdong, although DENV1-4 co-circulated in Guangdong. Twenty intra-serotype recombinant isolates involving DENV1-4 were detected, but no inter-serotype recombinant events were identified in this study. Additionally, the most recombinant events were detected simultaneously in the geneNS3 of DENV1-4. Nucleotide variation analyses showed that no significant intra-serotype differences were observed, whereas more significant inter-subtype differences were discovered in non-structural genes than in structural genes. Our investigation will facilitate the understanding of the current prevalent status of dengue fever in Guangdong and contribute to designing more effective preventive and control strategies for dengue infection.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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by Jue Tao Lim, Borame Sue Dickens, Sun Haoyang, Ng Lee Ching, Alex Richard Cook Dengue, a mosquito-borne infectious disease caused by the dengue viruses, is present in many parts of the tropical and subtropical regions of the world. All four serotypes of dengue viruses are endemic in Singapore, an equatorial city-state. Frequent outbreaks occur, sometimes leading to national epidemics. However, few studies have attempted to characterize breakpoints which precede large rises in dengue case counts. In this paper, Bayesian regime switching (BRS) models were employed to infer epidemic and endemic regimes of dengue transmissi...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
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Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Sporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-borne dengue viruses (DENV) and Culex-borne flaviviruses. We hypothesized that this incongruence reflects interspecies recombination resulting in ZIKV evasion of cross-protective T-cell immunity. We investigated ZIKV phylogenetic i...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
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Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research
Climate change is the greatest health challenge of the 21st century, and threatens all aspects of society, says the WHO in its COP24 Special Report. What could digital health technologies do to support the fight against the climate crisis? How could healthcare processes, facilities, medical devices become more sustainable? As it is humanity’s priority to mitigate the worsening as well as the impact of rising temperatures and extreme weather events, we tried to figure out what role digital health could assume here. We found many options – and even more possibilities for future development. The climate crisis...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine air asthma climate climate catastrophe climate change climate crisis digital digital health efficient Healthcare mosquito optimize resilience solar sustainability technology Source Type: blogs
Abstract Population displacement and other forced movement patterns following natural disasters, armed conflicts or due to socioeconomic reasons contribute to the global emergence of Aedes-borne viral disease epidemics. In particular, dengue epidemiology is critically affected by situations of displacement and forced movement patterns, particularly within and across borders. In this respect, waves of human movements have been a major driver for the changing epidemiology and outbreaks of the disease on local, regional and global scales. Both emerging dengue autochthonous transmission and outbreaks in countries know...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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