CX3CR1 contributes to streptozotocin-induced mechanical allodynia in the mouse spinal cord.

CX3CR1 contributes to streptozotocin-induced mechanical allodynia in the mouse spinal cord.
J Zhejiang Univ Sci B. 2020 Feb.;21(2):166-171
Authors: Ni CM, Ling BY, Xu X, Sun HP, Jin H, Zhang YQ, Cao H, Xu L
Abstract
Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life (Abbott et al., 2011), by causing sleeping disorders, anxiety, and depression (Dermanovic Dobrota et al., 2014). The primary clinical manifestation of painful diabetic neuropathy (PDN) is mechanical hypersensitivity, also known as mechanical allodynia (MA) (Callaghan et al., 2012). MA's underlying mechanism remains poorly understood, and so far, based on symptomatic treatment, it has no effective therapy (Moore et al., 2014).
PMID: 32115913 [PubMed - in process]

Source: J Zhejiang Univ Sci ... - January 31, 2020 Category: Science Authors: Ni CM, Ling BY, Xu X, Sun HP, Jin H, Zhang YQ, Cao H, Xu L Tags: J Zhejiang Univ Sci B Source Type: research