Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection

ConclusionsMutations in ciliopathy-relatedSPAG6 andRSPH3 cause severe asthenoteratospermia characterized by multiple flagellar malformations, resulting in sterility. ICSI is an optimal management with a positive pregnancy outcome.

Source: Journal of Assisted Reproduction and Genetics - March 1, 2020 Category: Reproduction Medicine Source Type: research