Infection by Brazilian and Dutch swine hepatitis E virus strains induces haematological changes in Macaca fascicularis

Conclusions:
The ability of HEV to cross the species barrier was confirmed for both the swine (Brazilian and Dutch) and human (Argentinean) strains, thus reinforcing the zoonotic risk of hepatitis E in South America. Cynomolgus monkeys that were infected with HEV genotype 3 developed subclinical hepatitis that was associated with haematological changes. Haematological approaches should be considered in future studies of HEV infection.

Source: BMC Infectious Diseases - October 23, 2013 Category: Infectious Diseases Authors: Lilian de CarvalhoRenato MarchevskyDebora dos SantosJaqueline de OliveiraVanessa de PaulaLeilane LopesWilhelmus Van der PoelJorge GonzálezMaria MunnéJulio MoranAna CajaravilleMarcelo Pelajo-MachadoOswaldo CruzMarcelo Pinto Source Type: research