Influence of the integrin alpha-1 subunit and its relationship with high-fat diet upon extracellular matrix synthesis in skeletal muscle and tendon

In conclusion, HFD induced a significant increase i n expression of ECM genes in muscle. On the protein level, HFD resulted in a lower collagen content in muscle. Tendons were unaffected by the diet. Deletion of the integrin α1 subunit did not affect collagen protein or gene expression in muscle or tendon.

http://link.springer.com/10.1007/s00441-020-03184-y

Source: Cell and Tissue Research - February 27, 2020 Category: Cytology Source Type: research