Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro ‐β‐erythroidine in nicotine‐tolerant mice

ConclusionsThe differential antagonism of rate ‐decreasing and hypothermic effects implicates differential involvement of nAChR subtypes. The decreased capacity of mecamylamine and DHβE to antagonize nicotine during chronic nicotine treatment may indicate that their effectiveness as smoking cessations might vary as a function of nicotine tole rance and dependence.

Source: Brain and Behavior - February 27, 2020 Category: Neurology Authors: Fernando B. Moura, Jenny L. Wilkerson, Lance R. McMahon Tags: ORIGINAL RESEARCH Source Type: research