Par-4 Downregulation Confers Cisplatin Resistance in Pancreatic Cancer Cells via PI3K/Akt Pathway-dependent EMT.

In conclusion, these results indicate that Par-4 downregulation confers CDDP resistance via PI3K/Akt pathway-dependent EMT in BXPC-3 cells. Therefore, Par-4 may be a potential target for overcoming CDDP resistance in pancreatic cancer.
PMID: 24144893 [PubMed - as supplied by publisher]

Source: Toxicology Letters - October 18, 2013 Category: Toxicology Authors: Tan J, You Y, Xu T, Yu P, Wu D, Deng H, Zhang Y, Bie P Tags: Toxicol Lett Source Type: research