Down-regulation of IDH2 sensitizes cancer cells to erastin-induced ferroptosis.

This study supports that IDH2 has protective effect against ferroptotic cell death, and that the enzyme could be targeted to sensitize cancer cells to ferroptosis. PMID: 32089268 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32089268?dopt=Abstract

Source: Biochemical and Biophysical Research communications - February 20, 2020 Category: Biochemistry Authors: Kim H, Lee JH, Park JW Tags: Biochem Biophys Res Commun Source Type: research