Fatal clinical outcome in a patient with sarcoidosis-lymphoma syndrome.

Fatal clinical outcome in a patient with sarcoidosis-lymphoma syndrome. Pneumonol Alergol Pol. 2013;81(6):542-9 Authors: Goljan-Geremek A, Puścińska E, Bednarek M, Nowiński A, Kamiński D, Ptak J, Bestry I, Langfort R, Staszewska M, Gorecka D Abstract A 62-year-old female suspected of malignant disease underwent a splenectomy that revealed noncaseating granulomas in the histological specimen. Chest X-ray (CXR) and lung CT scans suggested sarcoidosis stage II. TBLB showed noncaseating granulomas. A diagnosis of sarcoidosis was made. Initially no treatment was needed as partial remission on CXR and normal lung function were observed. During the follow up she underwent open lung biopsy and axillary lymph node biopsy because of radiological progression with presence of CXR opacities imitating metastases and recurrent lymphadenopathy. No malignant cells were found. Spontaneous partial resolution of disseminated changes on the CXR was observed. Because of progressive deterioration in lung function and the clinical course of the disease strongly suggesting the progression of systemic sarcoidosis, the patient was given steroid treatment, which initially resulted in partial remission of pulmonary disseminated changes, peripheral lymphadenopathy and improvement in lung function test. Eight months later severe deterioration in general condition, anaemia, leukocytosis, hypoxemia, massive hepatomegaly and recurrence of general lymphadenopathy along with progression of ...
Source: Pneumonologia i Alergologia Polska - Category: Respiratory Medicine Authors: Tags: Pneumonol Alergol Pol Source Type: research

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ConclusionsThe exposure –response analysis suggested that intermittent 7-day veliparib 120 mg BID dosing in a 21-day cycle provided additional efficacy without meaningfully impacting the safety and tolerability when co-administered with carboplatin and paclitaxel in patients with BRCA-deficient breast cancer. A higher d ose of veliparib is unlikely to provide greater benefit in this combination in patients with BRCA-deficient recurrent or metastatic breast cancer.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Authors: Xiao W, Hu C, Chu C, Man Y Abstract This prospective pilot study presents a novel method using the dentin shell technique for the three-dimensional reconstruction of alveolar bone defects. Autogenous dentin shell (≤ 2 mm) harvested from impacted third molars was fixed at the recipient site as an external barrier. The space between the dentin shell and residual bone was filled with deproteinized bovine bone mineral particles mixed with concentrated growth factor (CGF) pieces. Autogenous bone (gold standard for bone graft) was applied to prepare shell grafts as the control. A total of 13 patients were inc...
Source: International Journal of Periodontics and Restorative Dentistry - Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research
Authors: Fistarol F, De Stavola L, Fincato A, Bressan E Abstract The aim of this study is to evaluate the anatomical characteristics of the posterior region of the mandible and their surgical relevance related to bone harvesting procedures. Fifty retromolar cone beam computed tomography scans were analyzed considering the donor site anatomies. For each site, linear measurements were taken of cross-sectional scans to record perpendicular distances between the mandibular canal (MC) and the vestibular and crestal bone walls. Data showed that the distance from the MC to the vestibular bone wall is lower in the ramus ar...
Source: International Journal of Periodontics and Restorative Dentistry - Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research
The objective of this study was to compare the novel extraction-site development (XSD) technique with spontaneous healing. Advanced alveolar defects (extraction defect sounding, classes 3 and 4) at 33 single-rooted teeth were treated by XSD (test), and 21 extraction sites of single-rooted teeth were left for spontaneous healing (control). In pre- and postoperative cone beam computed tomography (CBCT) data sets, orovestibular and vertical socket dimensions were assessed, as were socket areas. XSD resulted in complication-free healing with significantly higher radiographic bone fill compared to spontaneous healing. Applicati...
Source: International Journal of Periodontics and Restorative Dentistry - Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research
ConclusionMTV and TLG reflecting the metabolic tumor burden can predict OS in patients with advanced lung adenocarcinoma.ResumenObjetivoEl presente estudio evalúa el valor pronóstico de los parámetros metabólicos relacionados con el tumor primario en el 18F-FDG PET/TC pretratamiento en pacientes con adenocarcinoma pulmonar en fase avanzada.Materiales y métodosEste estudio retrospectivo incluyó 258 pacientes con adenocarcinoma pulmonar en fase avanzada a los que se les realizó un escáner PET/TC del pretratamiento y para quienes estaba disponible el receptor del factor ...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Publication date: Available online 15 October 2019Source: Materials Today: ProceedingsAuthor(s): B. Ramanjaneyulu, N. Venkatachalapathi, G. PrasanthiAbstractIn this research paper explores about biodegradable polymers such as Poly lactic acid (PLA), Acrylonitrile-Butadiene-Styrene (ABS) and Tapioca cassava starch powder (TCSP) and their blends prepared using conventional method. The prepared bio degradable polymer blends are analyzed with the help of Universal testing machine (UTM-3969), scanning electron microscopy (SEM).On the weight basis PLA, ABS, and TCSP are transferred into binary and ternary blends such as PLA, ABS...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 15 October 2019Source: Materials Today: ProceedingsAuthor(s): A. Gowtham, G. Chaitanya, Jitendra Kumar Katiyar, Aayush Chandak, T.V.K. GuptaAbstractLaser cladding is an emerging technology for depositing coating material over the substrate with less dilution (
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 15 October 2019Source: CarbonAuthor(s): Bin Liu, Xiaofang Hu, Yongcun Li, Tiqiao Xiao, Feng XuAbstractResearch on internal three-dimensional (3D) strain evolution of a failure process was conducted on a short carbon fiber-reinforced composite through high-resolution (0.33 μm/pixel) in situ synchrotron radiation X-ray computed tomography. Material microstructure and strain value were analyzed simultaneously in 3D for the first time. The distribution of strain fields is nonuniform under load sequences. They are very difference that the strain evolution of the 3D morphological feature, th...
Source: Carbon - Category: Materials Science Source Type: research
This study demonstrates a simple strategy to produce lightweight porous 3D CS/GO composite foams with biocompatibility, electrical conductivity, and decent mechanical and viscoelastic properties regulated by the composition. These foams are promising materials applicable in biomedical and environmental engineering and electrical devices.Graphical abstract
Source: Carbon - Category: Materials Science Source Type: research
Neal McCluskeyIf you were expecting big steps forward on the Higher Education Act from the House Committee on Education and Labor, prepare to be disappointed. Yesterday, the Democratic majority released theCollege Affordability Act—which for some reason says “Est. 2019”—and it delivers pretty much what we’ve seen established since about 1969: A general conviction that what higher ed mainly needs is more government money…and no openly for-profit schools.The centerpieces of the bill are federal funds to encourage states to make community colleges free, increases in Pell Grants, cheaper st...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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