IJERPH, Vol. 17, Pages 1441: Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review
IJERPH, Vol. 17, Pages 1441: Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041441
Authors:
Marco Capece
Massimiliano Creta
Armando Calogero
Roberto La Rocca
Luigi Napolitano
Biagio Barone
Antonello Sica
Ferdinando Fusco
Michele Santangelo
Concetta Anna Dodaro
Caterina Sagnelli
Nicola Carlomagno
Felice Crocetto
Gianluigi Califano
Francesco Mangiapia
Nicola Longo
Background: Prostate cancer (PCa) represents a common disease in men aged >65 years. The role of physical activity (PA) in patients at risk or diagnosed with PCa represents an evolving issue. We aimed to summarize available evidences about the impact of PA on the pathophysiology and clinical outcomes of PCa. Methods: We performed a narrative review. Evidences about the role of PA in elderly patients in terms of PCa biology, epidemiology, oncological and functional outcomes, as well as in terms of impact on the outcomes of androgen deprivation therapy (ADT) were summarized. Results: Potential pathophysiological pathways hypothesized to explain the benefits of PA in terms of prostate carcinogenesis include circulating levels of Insulin-like growth factor-1 (IGF-1), oxidative stress, systemic inflammation, sex hormones, and myokines. Clinically, emerging evidences support the hypothesis that PA is associated with decreased PCa ris...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Marco Capece Massimiliano Creta Armando Calogero Roberto La Rocca Luigi Napolitano Biagio Barone Antonello Sica Ferdinando Fusco Michele Santangelo Concetta Anna Dodaro Caterina Sagnelli Nicola Carlomagno Felice Crocetto Gianluigi Califano Francesco Mangi Tags: Review Source Type: research
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