IJERPH, Vol. 17, Pages 1441: Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review

IJERPH, Vol. 17, Pages 1441: Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041441 Authors: Marco Capece Massimiliano Creta Armando Calogero Roberto La Rocca Luigi Napolitano Biagio Barone Antonello Sica Ferdinando Fusco Michele Santangelo Concetta Anna Dodaro Caterina Sagnelli Nicola Carlomagno Felice Crocetto Gianluigi Califano Francesco Mangiapia Nicola Longo Background: Prostate cancer (PCa) represents a common disease in men aged >65 years. The role of physical activity (PA) in patients at risk or diagnosed with PCa represents an evolving issue. We aimed to summarize available evidences about the impact of PA on the pathophysiology and clinical outcomes of PCa. Methods: We performed a narrative review. Evidences about the role of PA in elderly patients in terms of PCa biology, epidemiology, oncological and functional outcomes, as well as in terms of impact on the outcomes of androgen deprivation therapy (ADT) were summarized. Results: Potential pathophysiological pathways hypothesized to explain the benefits of PA in terms of prostate carcinogenesis include circulating levels of Insulin-like growth factor-1 (IGF-1), oxidative stress, systemic inflammation, sex hormones, and myokines. Clinically, emerging evidences support the hypothesis that PA is associated with decreased PCa ris...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research