Bacterial manganese sensing and homeostasis.

Bacterial manganese sensing and homeostasis.
Curr Opin Chem Biol. 2020 Feb 18;55:96-102
Authors: Waters LS
Abstract
Manganese (Mn) plays a complex role in the survival of pathogenic and symbiotic bacteria in eukaryotic hosts and is also important for free-living bacteria to thrive in stressful environments. This review summarizes new aspects of regulatory strategies to control intracellular Mn levels and gives an overview of several newly identified families of bacterial Mn transporters. Recent illustrative examples of advances in quantification of intracellular Mn pools and characterization of the effects of Mn perturbations are highlighted. These discoveries help define mechanisms of Mn selectivity and toxicity and could enable new strategies to combat pathogenic bacteria and promote growth of desirable bacteria.
PMID: 32086169 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - February 17, 2020 Category: Biochemistry Authors: Waters LS Tags: Curr Opin Chem Biol Source Type: research