Estrogen and Calcium Handing Proteins: New Discoveries and Mechanisms in Cardiovascular Diseases.

Estrogen and Calcium Handing Proteins: New Discoveries and Mechanisms in Cardiovascular Diseases. Am J Physiol Heart Circ Physiol. 2020 Feb 21;: Authors: Jiao L, Machuki JO, Wu Q, Shi M, Fu L, Adekunle AO, Tao X, Xu C, Hu X, Yin Z, Sun H Abstract Estrogen deficiency is considered to be an important factor leading to cardiovascular diseases (CVDs). Indeed, the prevalence of CVDs in postmenopausal women exceeds that of premenopausal women and men of same age. Recent research findings provide evidence that estrogen plays a pivotal role in the regulation of calcium homeostasis, and hence fine-tunes normal cardiomyocytes contraction and relaxation processes. Disruption of calcium homeostasis is closely associated with the pathological mechanism of CVDs. Thus, this article maps out and summarizes the effects and mechanisms of estrogen on calcium handing proteins in cardiac myocytes, including L-type Ca2+ channel (LTCC), sarcoplasmic reticulum (SR) Ca2+ release channel named ryanodine receptor (RyR), sarcoplasmic reticulum calcium ATPase (SERCA), and sodium-calcium exchanger (NCX). In so doing, we provide theoretical and experimental evidence for the successful design of estrogen-based prevention and treatment therapies for CVDs. PMID: 32083972 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research