Etv2- and Fli1-Induced Vascular Progenitor Cells Enhance Functional Recovery in Ischemic Vascular Disease Model.

CONCLUSIONS: We demonstrate that ischemic disease curable iVPCs, which have self-renewal and bipotency, can be generated from mouse fibroblasts by enforced ETS family transcription factors, Etv2 and Fli1 expression. Our simple strategy opens insights into stem cell-based ischemic disease therapy.
PMID: 32075417 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 19, 2020 Category: Cardiology Authors: Park SY, Lee H, Kwon YW, Park MR, Kim JH, Kim JB Tags: Arterioscler Thromb Vasc Biol Source Type: research