Advances in endoscopy for colorectal polyp detection and classification.

Advances in endoscopy for colorectal polyp detection and classification. Proc (Bayl Univ Med Cent). 2020 Jan;33(1):28-35 Authors: Pamudurthy V, Lodhia N, Konda VJA Abstract While colonoscopy is considered the gold standard for colon cancer screening, recent advancements in endoscopes have allowed for improved visualization of the colonic mucosa and improved polyp detection rates. Newer technologies also allow for assessment of structural changes for polyp discrimination and determination of histologic type. Classification of polyps prevents the need for a histopathologic report, which requires the additional time and expertise of a pathologist and adds to the overall cost. This review considered advances in endoscopic technologies reported in PubMed over the past 12 years. Technologies that allow for increased visual field of colonic mucosa and may lead to improved colon polyp detection rates include cap-assisted colonoscopy, RetroView, extra-wide-angle view colonoscope, full-spectrum endoscopy, Third Eye Retroscope, NaviAid G-EYE balloon colonoscope, EndoRings, and Endocuff. Image-enhancing methods allow for pit pattern analysis of colorectal lesions, which enables the physician to classify colorectal polyps according to certain polyp characteristics. Image-enhancing methods include chromoendoscopy, autofluorescence, and virtual chromoendoscopy, including narrow band imaging, i-SCAN, flexible spectral imaging chromoendoscopy, and STORZ professional imag...
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research

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In this study, we examined whether HASPIN inhibitor CHR-6494 suppresses cancer progression in ApcMin/+ mice, a familial colon tumor disease model. Mice were treated by intraperitoneal injection of CHR-6494 for 50 days. Following the treatment period, intestinal polyps were counted and testosterone and spermatogenesis levels were observed. Intraperitoneal administration of CHR-6494 significantly inhibited intestinal polyp development and recovered body weight in ApcMin/+ mice. Although spermatogenesis was inhibited with increasing age in ApcMin/+ mice, CHR-6494 significantly improved blood testosterone levels and spermatoge...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Gastrointestinal cancer Source Type: research
Colonoscopy is the most commonly performed endoscopic examination worldwide and is considered the gold standard for colorectal cancer screening.The quality of examination and endoscopic treatment is affected by a number of factors that are verified by recognized parameters, such as cecal intubation rate and time, withdrawal time, adenoma detection rate and polyp detection rate.The aim of the study was to assess the suitability of 330-degree panoramic colonoscopy for the detection of colorectal lesions and to analyze the functionality of a special endoscope series in regard to cecal intubation rate, cecal intubation time, and withdrawal time.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Colon and rectal surgery Source Type: research
Conclusions: Adenomatous polyps are very important in childhood because of rarity. In particular, the presence of cafe au lait spots and a history of malignancy detected in relatives at an early age must be considered for CMMRD.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
AbstractPurposeIGF-1Ec is an isoform of Insulin-like growth factor 1 (IGF-1) and has recently been identified to be overexpressed in cancers including prostate and neuroendocrine tumours. The aim of this paper is to investigate the expression of IGF-1Ec in colorectal cancer and polyps compared to normal colon tissues and its association with recurrent disease using semi-quantitative immunohistochemistry.MethodsImmunohistochemistry for IGF-1Ec expression was performed for colorectal cancer, colorectal polyps and normal colonic tissues. The quantification of IGF-1Ec expression was performed with the use of Image J software a...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
A 64-year-old man presented with large colon polyp detected by screening colonoscopy. The colonoscopy showed a 20-mm pedunculated polyp with a thick and bulging stalk in the sigmoid colon (Figure A). Endoscopic ultrasonography revealed that the stalk consisted of a low echoic structure in the submucosa, considering of a cystic component (Figure B, arrows). Although the polyp was suspected of an invasive cancer, biopsies from the polyp head revealed tubular adenoma. Endoscopic resection was performed for pathological diagnosis and local treatment at the patient ’s request.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Electronic Image of the Month Source Type: research
Conclusion Incomplete polyp resection was frequent after polypectomy in routine clinical practice. Serrated histology and proximal location were independent risk factors for incomplete resection. The performance of board-certified gastroenterologists was not superior to that of trainees. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
(Ohio State University) Researchers have found a way to send tiny, soft robots into humans, potentially opening the door for less invasive surgeries and ways to deliver treatments for conditions ranging from colon polyps to stomach cancer to aortic artery blockages.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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Source: WebMD Health - Category: Consumer Health News Source Type: news
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Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Conditions:   Colo-rectal Cancer;   Polyp of Colon;   Adenomatous Polyp of Colon Interventions:   Device: Use of EverLift;   Device: Without use of EverLift Sponsor:   Stanford University Recruiting
Source: - Category: Research Source Type: clinical trials
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