Ceftaroline versus Vancomycin in The Treatment of Methicillin-resistant Staphylococcus aureus in an Experimental MRSA Meningitis Model

Publication date: Available online 14 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Sinan Mermer, Tuncer Turhan, Elif Bolat, Sohret Aydemir, Tansu Yamazhan, Husnu Pullukcu, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy, Oguz Resat SipahiAbstractObjectivesHerein, we aimed to compare the antibacterial activity of ceftaroline and vancomycin in the treatment of MRSA meningitis in experimental rabbit meningitis model.MethodsWe compared the antibacterial activity of ceftaroline with vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid cultures were performed at the beginning, 24 and 73 hours after the first antibiotic dose. Furthermore, in vitro time-kill data were investigated at 0, 2, 4, 6, 8, 12 and 24th hours in sterile human serum.ResultsThe difference between the control group vs. both treatment groups was significant when the decrease of colony counts in CSF at both 24 and 73 hours after the first antibiotic dose was compared (p 
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research

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Publication date: Available online 14 January 2020Source: Journal of Acupuncture and Meridian StudiesAuthor(s): Renuka T. Rudra, Vitaly Gordin, Lihua Xu
Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
In conclusion, the insect-derived strain of S. globisporus WA5-2-37 was considered of great potential as a new strain of producing actinomycin X2, collismycin A or other anti-MRSA compounds.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
The objective of this study was to apply an in vitro bioguided approach using as a model system the mollicutes with a sample of propolis from the Brazilian native bee Melipona quadrifasciata (mandaçaia) in order to identify potential new molecules with antimicrobial activity. A crude hydroalcoholic extract was obtained and submitted to liquid-liquid partitioning with solvents of different polarities, generating four different fractions: aqueous, dichloromethane, butanol, and ethyl acetate fractions. The antimollicute activity assays served as a basis for the bioguided fractionation. The dichloromethane fraction was ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
There is an urgent need for new antimicrobials to treat the opportunistic Gram-negative Burkholderia cenocepacia, which represents a problematic challenge for cystic fibrosis patients. Recently, a benzothiadiazole derivative, C109, was shown to be effective against the infections caused by B. cenocepacia and other Gram-negative and-positive bacteria. C109 has a promising cellular target, the cell division protein FtsZ, and a recently developed PEGylated formulation make it an attractive molecule to counteract Burkholderia infections. However, the ability of efflux pumps to extrude it out of the cell represents a limitation...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
te;dérick Arnaud Alain Kohl Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found in the countries surrounding the Mediterranean. TOSV is an important cause of seasonal acute meningitis and encephalitis within its range. Here, we determined the full sequence of the TOSV strain 1500590, a lineage A virus obtained from an infected patient (Marseille, 2007) and used this in combination with other sequence information to construct functional cDNA plasmids encoding the viral L, M, and S antigenomic sequences under the control of the T7 RNA promoter to recover recombinant virus...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This study represents the first characterization of a mobilizable antibiotic resistance island in a species of Rheinheimera and provides evidence that Rheinheimera spp. could be important reservoirs and vehicles for ARGs in the Yellow Sea area.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
cala Gulino Fragalà Zinc oxide (ZnO) nanorods grown by chemical bath deposition (CBD) on the surface of polyetheresulfone (PES) electrospun fibers confer antimicrobial properties to the obtained hybrid inorganic–polymeric PES/ZnO mats. In particular, a decrement of bacteria colony forming units (CFU) is observed for both negative (Escherichia coli) and positive (Staphylococcus aureus and Staphylococcus epidermidis) Grams. Since antimicrobial action is strictly related to the quantity of ZnO present on surface, a CBD process optimization is performed to achieve the best results in terms of coverag...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Conclusion. Spinal infection in the presence of liver cirrhosis is challenging. The rate epidural abscess formation is relatively high. Early diagnosis remains the main cornerstone in the management and the indication for surgery should be carefully considered. Minimally invasive techniques should be used when possible to minimize complication rate, and higher amounts of intraoperative blood loss should be expected. Level of Evidence: 4
Source: Spine - Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research
As America ’s biopharmaceutical companies workaround the clock to combat COVID-19, a disease caused by a novel strain of coronavirus, now is an important time to consider how we can prepare for the next public health emergency: Antimicrobial resistance (AMR). AMR occurs when microorganisms such as bacteria, viruses, fungi and parasites change in ways that make the medications used to cure the infections they cause ineffective. According to the Centers for Disease Control and Prevention (CDC), more than 2.8 million antibiotic-resistant infections occur in the U.S. each year, and more than 35,000 people die as a r...
Source: The Catalyst - Category: Pharmaceuticals Tags: Research and Development PhRMA Member Company Infectious Diseases Coronavirus Source Type: news
Authors: Bielefeld V, Assad S, Guguen C, Goupil F, Le Meur G, Lebranchu P, Laballe R PMID: 32245580 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
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