Screening of characteristic biomolecules related to bladder cancer based on construction of ceRNA regulation network

ConclusionsIn bladder cancer tumor samples, samples down-regulated by LINC01198, PPTRD-AS1, has-miR-216a, SEMA3D, EPHA5, and DCLK1 had a good overall survival prognosis, indicating that these several characteristic target molecules were found to be high-risk factors for bladder cancer tumors.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research

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Authors: Shahid M, Kim M, Yeon A, Jin P, Kim WK, You S, Kim J Abstract PURPOSE: Pioglitazone, an antihyperglycemic drug, is widely used in diabetes mellitus patients with insulin resistance. Although pioglitazone is known to have a potential link to bladder cancer (BC), there have been contradictory results. This present study is designed to understand the regulatory mechanisms that drive the effects of pioglitazone on the bladder epithelial cells. METHODS: Labeled liquid chromatography-tandem mass spectrometry-based proteomics profiling characterized the global proteomes of normal human bladder epithelial cell...
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
This perspective paper presents the case for adopting a new approach to the design and delivery of supportive care for those with bladder cancer. It is our assertion that the design and delivery of supportive care for those diagnosed with bladder cancer needs to (1) build on existing research and available tools and (2) address current limitations due to lack of use of said tools, lack of understanding of research and needs, lack of a shared language, and method of assessment and evaluation. This, we argue, can be achieved through a network-based approach (1) focussed on the structure, process, and outcome of supportive care.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions18F-Azafol is a PET agent with favorable dosimetric properties and a reasonable radiation dose burden for patients which merits further evaluation to assess its performance.Trial registrationClinicalTrial.gov,NCT03242993, posted on August 8, 2017
Source: EJNMMI Research - Category: Radiology Source Type: research
POP-RT trial by Murthy, et al [1] addresses the impact of addition of elective pelvic irradiation (WPRT) in node negative locally advanced prostate cancer (PC). Although the primary endpoint of biochemical progression free survival has not been reported yet, the study showed that there is a significant increase in late grade 2+ genitourinary (GU) toxicity in patients who received WPRT. The authors noted that this corresponded to irradiation of urinary bladder (UB) to doses between 30-50Gy. We congratulate the authors for this important study and would like to present the following observations:
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
Conclusion: Ho laser ERBT is safe and feasible for complete resection of NMIBCs with no risk of obturator-nerve reflex and a high rate of detrusor-positive specimens.
Source: Indian Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionsWith good inter-observer concordance, the 2004 WHO classification system of noninvasive bladder tumours appears to accurately predict recurrence and progression risks. The combination of both grading systems to low-grade tumours allows further refinement of the natural history.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
The transcriptional data of circRNAs and mRNAs were deeply detected by high ‐throughput RNA sequencing and systematically analyzed using bioinformatics in patients with BC; and these eight dysregulated circRNAs were also verified by real‐time qRT‐PCR. Correlation analysis of clinicopathological features and survival analyses of circRNAs in BC were conducted. Functiona l experiments with circ_0077837 and circ_0004826 overexpression significantly weakened the progression of BC cells. AbstractGrowing evidence has indicated that circular RNAs (circRNAs) play crucial roles in multiple biological processes. However, altera...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionIn the feasibility phase, the panel of urine biomarkers analyzed detected and predicted recurrence of NMIBC and provided reliable results in patients who had previously used intravesical BCG. Validation studies are required to confirm the panel clinical utility.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
AbstractPurposeTo assess the spectrum of computed tomography (CT) findings in patients with genitourinary cancers visiting the emergency room (ER) and evaluate the relationship between CT findings and overall survival (OS).MethodsRetrospective analysis of consecutive patients with genitourinary cancers undergoing CT during an ER visit at a tertiary cancer center during a 20-month period. CTs were considered positive if there were findings relevant to the presenting complaint(s). Demographic/clinical variables were recorded. OS was evaluated using Kaplan-Meier curves. Univariate and multivariate Cox proportional hazards reg...
Source: Emergency Radiology - Category: Emergency Medicine Source Type: research
Authors: Muşină AM, Huţanu I, Grigore M, Scripcariu IS, Filip B, Aniţei MG, Scripcariu DV, Gavrilescu MM, Radu I, Ioanid N, Pantazescu AN, Hogea M, Panuţa A, Buna-Arvinte M, Moraru GV, Scripcariu V Abstract Pelvic exenteration (PE) is an extensive surgical procedure for locally advanced primary neoplasia (LAPN) or recurrent neoplasia (RN) that consists in the en bloc removal of the pelvic organs (rectum, internal genital organs and bladder) associated with pelvic lymph nodes. PE is classified into anterior, posterior and total, supra or infralevatorian approaches. Our aim was to evaluate the surgical procedure...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
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